Book Holiday Homes in Los Santos

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Featured Holiday Homes in Los Santos

Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm

Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm

2 out of 5
Los Santos Province
Stay at this holiday home in Pedasí. Enjoy laundry facilities and an in-room coffee maker. Popular attractions Playa El Arenal and Playa El Toro are located ...
Opens in a new windowPedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm
Tropical Beachfront Home in Cambutal

Tropical Beachfront Home in Cambutal

Ave María Provincia de Los Santos
Stay at this beach holiday home in Cambutal. Enjoy a beach locale, a garden and balconies. Popular attractions Los Buzos Beach and Guanico Abajo Beach are located ...
Opens in a new windowTropical Beachfront Home in Cambutal
Chic 1-bedroom with WiFi and AC in enchanting Río Hato

Chic 1-bedroom with WiFi and AC in enchanting Río Hato

Río Hato Provincia de Coclé
Stay at this holiday home in Rio Hato. Enjoy air conditioning. Popular attractions Playa Blanca and Farallón Beach are located nearby.
Opens in a new windowChic 1-bedroom with WiFi and AC in enchanting Río Hato
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Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

El Chirú Provincia de Coclé
Stay at this holiday home in El Chiru. Enjoy laundry facilities, an in-room coffee maker and air conditioning. Popular attractions Playa Blanca and Farallón ...
Opens in a new windowSanta Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.
Santa Clara ocean front beach house… from your lawn right onto the sand.

Santa Clara ocean front beach house… from your lawn right onto the sand.

Santa Clara Cocle
Stay at this holiday home in Rio Hato. Enjoy free Wi-Fi, private pools and a garden. Popular attractions Playa Blanca and Farallón Beach are located nearby.
Opens in a new windowSanta Clara ocean front beach house… from your lawn right onto the sand.
Panama Santa Clara Beach Residence

Panama Santa Clara Beach Residence

Cocle Cocle
Stay at this holiday home in Rio Hato. Enjoy free Wi-Fi, private pools and a beach locale. Popular attractions Playa Blanca and Farallón Beach are located ...
Opens in a new windowPanama Santa Clara Beach Residence
GoldSky Hacienda with pool

GoldSky Hacienda with pool

Rio Hato Coclé Province
Stay at this golf holiday home in Rio Hato. Enjoy free Wi-Fi, private pools and a garden. Popular attractions Playa Blanca and Farallón Beach are located ...
Opens in a new windowGoldSky Hacienda with pool
Beach House / 6 People / Pool / Pet Friendly / Tourist Area

Beach House / 6 People / Pool / Pet Friendly / Tourist Area

Río Hato Provincia de Coclé
Stay at this beach holiday home in Rio Hato. Enjoy free Wi-Fi, a beach locale and a garden. Popular attractions Playa Blanca and Farallón Beach are located ...
Opens in a new windowBeach House / 6 People / Pool / Pet Friendly / Tourist Area
Beachfront home + private pool, Playa Venao, Sleeps 10+

Beachfront home + private pool, Playa Venao, Sleeps 10+

Playa Venao Provincia de Los Santos
Stay at this holiday home in Las Escobas del Venado. Enjoy private pools, a beach locale and a garden. Popular attraction Venao Beach is located nearby.
Opens in a new windowBeachfront home + private pool, Playa Venao, Sleeps 10+
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Los Santos Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Los Santos vacation homes are the perfect way for you to wing it.

Holiday houses in Los Santos let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Los Santos in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Los Santos adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Los Santos with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Los Santos vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Los Santos Holiday Homes essential information

Accommodation
73 Holiday Homes
Lowest Price
NZ$95
Highest Price
NZ$400
Popular accommodation
Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm, Tropical Beachfront Home in Cambutal, Chic 1-bedroom with WiFi and AC in enchanting Río Hato, Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama., Santa Clara ocean front beach house… from your lawn right onto the sand., Panama Santa Clara Beach Residence, GoldSky Hacienda with pool, Beach House / 6 People / Pool / Pet Friendly / Tourist Area, Beachfront home + private pool, Playa Venao, Sleeps 10+

Top trending hotels in Los Santos

Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
Playa Venao Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
The price is NZ$400 per night from 5 Jan to 6 Jan
NZ$400
5 Jan - 6 Jan 2026
includes taxes & fees
Stay at this beach inn in Las Escobas del Venado. Enjoy free Wi-Fi, free parking and a beach locale. Our guests praise the helpful staff in their reviews. Popular ...
Opens in a new windowVilla Marina Lodge & Condos
Selina Playa Venao - Hostel

Selina Playa Venao - Hostel

3 out of 5
Playa Venao 1 Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
The price is NZ$95 per night from 25 Dec to 26 Dec
NZ$95
25 Dec - 26 Dec
includes taxes & fees
Stay at this beach hostel in Las Escobas del Venado. Enjoy free Wi-Fi, free parking and a beach locale. Popular attraction Venao Beach is located nearby.
Opens in a new windowSelina Playa Venao - Hostel
Selina River Venao

Selina River Venao

3 out of 5
Belisario Porras Avenue Las Escobas del Venado Provincia de Herrera
Fully refundableReserve now, pay when you stay
The price is NZ$134 per night from 21 Dec to 22 Dec
NZ$134
21 Dec - 22 Dec
includes taxes & fees
Stay at this hotel in Las Escobas del Venado. Enjoy free parking, breakfast (surcharge) and daily housekeeping. Popular attraction Venao Beach is located ...
Opens in a new windowSelina River Venao
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Casa Lajagua

Casa Lajagua

3 out of 5
Calle principal de Pedasi Pedasí Panama
The price is NZ$162 per night from 21 Dec to 22 Dec
NZ$162
21 Dec - 22 Dec
includes taxes & fees
Stay at this 3-star B&B in Pedasí. Enjoy free breakfast, free parking and an outdoor pool. Popular attractions Playa El Arenal and Playa El Toro are located ...
Opens in a new windowCasa Lajagua
Don't see what you're looking for?
See all available properties in Los Santos
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More ways to explore Los Santos

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^Subject to availability and chosen travel dates.