Book Holiday Homes in Santa Isabel

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Featured Holiday Homes in Santa Isabel

Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking

Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking

2 out of 5
Barranquitas
Stay at this holiday home in Barranquitas. Enjoy free Wi-Fi, balconies and an in-room coffee maker. Popular attraction Finca Don Felix para la Naturaleza is ...
Opens in a new windowCharming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking
The charming 11 minutes from the baths of Coamo. To feel at home!!!

The charming 11 minutes from the baths of Coamo. To feel at home!!!

Mariano Colon Coamo
Stay at this holiday home in Coamo. Enjoy laundry facilities, an in-room coffee maker and air conditioning. Popular attractions Coamo Springs and Playa La Ochenta ...
Opens in a new windowThe charming 11 minutes from the baths of Coamo. To feel at home!!!
A cozy place to stay walking distance from the beach and Restaurants.

A cozy place to stay walking distance from the beach and Restaurants.

Salinas Salinas
The price is NZ$272 per night from 29 Dec to 30 Dec
NZ$272
29 Dec - 30 Dec
includes taxes & fees
Stay at this holiday home in Salinas. Enjoy free Wi-Fi, a beach locale and patios. Popular attractions Marina de Salinas and Playa La Ochenta are located ...
Opens in a new windowA cozy place to stay walking distance from the beach and Restaurants.
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Casita La Ley en Cayey with 2-bedroom AC & WiFi.

Casita La Ley en Cayey with 2-bedroom AC & WiFi.

Cayey Puerto Rico
Stay at this holiday home in Cayey. Enjoy laundry facilities and air conditioning. Popular attractions Carribbean Cinemas Cayey and Carite State Forest are located ...
Opens in a new windowCasita La Ley en Cayey with 2-bedroom AC & WiFi.
3-bedroom house in Coamo with AC on bedroom 1

3-bedroom house in Coamo with AC on bedroom 1

Coamo Pr
The price is NZ$236 per night from 5 Jan to 6 Jan
NZ$236
5 Jan - 6 Jan 2026
includes taxes & fees
Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Coamo Historical Museum and Coamo Springs are located nearby.
Opens in a new window3-bedroom house in Coamo with AC on bedroom 1
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Santa Isabel Santa Isabel
The price is NZ$1,006 per night from 27 Dec to 28 Dec
NZ$1,006
27 Dec - 28 Dec
includes taxes & fees
Stay at this family-friendly holiday home in Santa Isabel. Enjoy free Wi-Fi, laundry facilities and balconies. Popular attractions Carribbean Cinemas Santa Isabel ...
Opens in a new windowHome in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Spacious Retreat with Private Jacuzzi and Tropical Patio

Spacious Retreat with Private Jacuzzi and Tropical Patio

Ponce Ponce
The price is NZ$363 per night from 30 Dec to 31 Dec
NZ$363
30 Dec - 31 Dec
includes taxes & fees
Stay at this holiday home in Ponce. Enjoy laundry facilities, balconies and in-room washers/dryers. Popular attractions Parque de la Ceiba and Teatro la Perla ...
Opens in a new windowSpacious Retreat with Private Jacuzzi and Tropical Patio
Tropical Ponce Home: Private Pool & Outdoor Oasis!

Tropical Ponce Home: Private Pool & Outdoor Oasis!

Ponce Puerto Rico
Stay at this holiday home in Ponce. Enjoy private pools, a garden and laundry facilities. Popular attractions El Museo Castillo Serralles and El Vigia Observation ...
Opens in a new windowTropical Ponce Home: Private Pool & Outdoor Oasis!
Oceanfront Escape, Hammocks, Walk to Boardwalk Solar Backup

Oceanfront Escape, Hammocks, Walk to Boardwalk Solar Backup

Arroyo Arroyo
Stay at this beach holiday home in Arroyo. Enjoy free Wi-Fi, a beach locale and a water park. Popular attractions Balneario Punta Guilarte and Playa Las Palmas ...
Opens in a new windowOceanfront Escape, Hammocks, Walk to Boardwalk Solar Backup
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santa Isabel Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Santa Isabel vacation homes are the perfect way for you to wing it.

Holiday houses in Santa Isabel let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Santa Isabel in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Santa Isabel adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Santa Isabel with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Santa Isabel vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Santa Isabel Holiday Homes essential information

Accommodation
106 Holiday Homes
Lowest Price
NZ$236
Highest Price
NZ$1,149
Popular accommodation
Charming house, stunning views in brilliant Barranquitas with AC, WiFi, Parking, The charming 11 minutes from the baths of Coamo. To feel at home!!!, A cozy place to stay walking distance from the beach and Restaurants., Casita La Ley en Cayey with 2-bedroom AC & WiFi., 3-bedroom house in Coamo with AC on bedroom 1, Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL, Spacious Retreat with Private Jacuzzi and Tropical Patio, Tropical Ponce Home: Private Pool & Outdoor Oasis!, Oceanfront Escape, Hammocks, Walk to Boardwalk Solar Backup

Top trending hotels in Santa Isabel

Hotel Las Vegas

Hotel Las Vegas

3 out of 5
PR 153, Km 2.9 Santa Isabel
Stay at this motel in Santa Isabel. Enjoy 24-hour room service, a 24-hour front desk and daily housekeeping. Our guests praise the helpful staff and the clean ...
Opens in a new windowHotel Las Vegas
Hacienda del Sur

Hacienda del Sur

2 out of 5
Carr 545 KM 1.5, Sector Gabia Santa Isabel
The price is NZ$263 per night from 25 Jan to 26 Jan
NZ$263
25 Jan - 26 Jan 2026
includes taxes & fees
Stay at this hotel in Santa Isabel. Enjoy free Wi-Fi, free parking and cable TV channels. Popular attractions Carribbean Cinemas Santa Isabel and Coamo Springs ...
Opens in a new windowHacienda del Sur
Caribbean Paradise – Oceanfront Villa with Infinity Pool & Garden Sanctuary

Caribbean Paradise – Oceanfront Villa with Infinity Pool & Garden Sanctuary

Santa Isabel PR
The price is NZ$1,149 per night from 26 Dec to 27 Dec
NZ$1,149
26 Dec - 27 Dec
includes taxes & fees
Stay at this holiday home in Santa Isabel. Enjoy free Wi-Fi, private pools and a garden. Popular attraction Carribbean Cinemas Santa Isabel is located ...
Opens in a new windowCaribbean Paradise – Oceanfront Villa with Infinity Pool & Garden Sanctuary
Save an average of 15% on thousands of hotels when you're signed in
Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Home in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL

Santa Isabel Santa Isabel
The price is NZ$1,006 per night from 27 Dec to 28 Dec
NZ$1,006
27 Dec - 28 Dec
includes taxes & fees
Stay at this family-friendly holiday home in Santa Isabel. Enjoy free Wi-Fi, laundry facilities and balconies. Popular attractions Carribbean Cinemas Santa Isabel ...
Opens in a new windowHome in Santa Isabel, Puerto Rico. 4BR 2BA home with WiFi, AC & UNDERGROUND POOL
Don't see what you're looking for?
See all available properties in Santa Isabel
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.