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21C Museum Hotel St Louis

4.5 star property

Photo gallery for 21C Museum Hotel St Louis

Restaurant
Exterior
Exterior
Bar (on property)
Massages

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning

Explore the area

View map
1528 Locust street, St. Louis, MO, 63103
  • Place, City Museum
    ‪5 min walk‬
  • Place, St. Louis Union Station
    ‪8 min walk‬
  • Place, Enterprise Center
    ‪8 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪20 min drive‬

Room options

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(106 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(33 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.4 out of 10
Very good
(7 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed
  • Free Wi-Fi

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds
  • Free Wi-Fi

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, Accessible (Accessible)

10.0 out of 10
Exceptional
(1 review)
  • 25 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Luxury Suite, 1 King Bed

A hotel room with a large bed, a green sofa, a small round table, and a large abstract painting on the wall.

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(2 reviews)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed
  • Free Wi-Fi

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed
  • Free Wi-Fi

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed
  • Free Wi-Fi

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About the area

St. Louis

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of St. Louis Union Station and City Museum. .This luxury hotel is 0.4 mi (0.7 km) from Enterprise Center and 0.7 mi (1.1 km) from America's Center Convention Complex.

What's nearby

  • Washington Avenue Historic District - 2 min walk - 0.2 km
  • City Museum - 5 min walk - 0.4 km
  • St. Louis Union Station - 8 min walk - 0.7 km
  • Enterprise Center - 8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station - 11 min walk - 1.0 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 24 min drive

Restaurants

  • ‪Imo's Pizza Headquarters & Retail Store - ‬7 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Blood & Sand - ‬2 min walk

About this property

21C Museum Hotel St Louis

21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk.
Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1272 out of 1804 reviews
Rating 8 - Good. 277 out of 1804 reviews
Rating 6 - Okay. 127 out of 1804 reviews
Rating 4 - Poor. 59 out of 1804 reviews
Rating 2 - Terrible. 69 out of 1804 reviews

9.2/10

Cleanliness

9.0/10

Staff & service

9.0/10

Amenities

9.2/10

Property conditions & facilities

Reviews

10/10 Excellent

Andrew

Liked: Cleanliness, staff & service, amenities
Very nice and clean
Stayed 1 night in Jan 2026

10/10 Excellent

Jessica

Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Room was great.
Stayed 1 night in Nov 2025

4/10 Poor

ANGELA

Business traveller, Travelled with family
Liked: Cleanliness
Disliked: Staff & service, amenities
Front desk staff was rude No parking so had to use valet, then had to wait forever to get our car
Stayed 2 nights in Jan 2026

10/10 Excellent

Joel

Stayed 2 nights in Jan 2026

10/10 Excellent

angela

Stayed 3 nights in Jan 2026

10/10 Excellent

Gwendolyn

Stayed 5 nights in Jan 2026

10/10 Excellent

Stacy

Travelled with family
Liked: Cleanliness, amenities, property conditions & facilities
Staff was great!
Stayed 1 night in Jan 2026

6/10 Okay

Seth

Liked: Cleanliness, staff & service, amenities
I really liked the hotel and the staff were very friendly. The room was clean, but the furnace had an issue and the room did not get warmer than 60 degrees. Beautiful place though and despite the issue we will visit again.
Stayed 1 night in Jan 2026

8/10 Good

Michelle

Liked: Cleanliness, staff & service, amenities
The hotel is nice/convenient to concert/sporting events downtown, and their bar is nice; had a bit of a hiccup trying to access their WiFi which needs addressing, but otherwise the property was very nice!
Stayed 1 night in Jan 2026

10/10 Excellent

ANDREA Nicole

Travelled with family
Liked: Cleanliness, staff & service, amenities
Always a wonderful stay! The staff is top notch and the space is perfect for the imaginative mind! Love love love!
Stayed 2 nights in Oct 2025

10/10 Excellent

Zoey

Stayed 1 night in Jan 2026

10/10 Excellent

NICHOLAS, Nashville

Business traveller
Liked: Cleanliness, amenities, property conditions & facilities
Loved the vibe
Stayed 3 nights in Jan 2026

10/10 Excellent

anthony

Stayed 4 nights in Dec 2025

10/10 Excellent

anthony

Liked: Cleanliness, staff & service, amenities
I love the 21C. It’s filled with character and charm. The staff is always super friendly. I stay here once or twice a month for work, never anything but a wonderful stay.
Stayed 4 nights in Jan 2026

8/10 Good

Kate

Stayed 2 nights in Jan 2026

10/10 Excellent

Mary

Stayed 5 nights in Jan 2026

10/10 Excellent

David

Stayed 1 night in Jan 2026

10/10 Excellent

Samantha

Liked: Cleanliness, staff & service, amenities
Room was clean and staff was very informative. Top tier customer service
Stayed 1 night in Jan 2026

8/10 Good

Kate

Travelled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great staff, cool amenities, amazing environment. We had a lot of fun with the penguins! ;)
Stayed 2 nights in Jan 2026

2/10 Terrible

John

Travelled with family
Liked: Cleanliness, property conditions & facilities, room comfort
Not sure what was up with the 2 who checked us in. The Asian guy was mid ok the black guy who processed everything was your worst employee we’ve had at any location. A front desk guy the next morning, 30’s black man, was beyond great and made up for the guy who did check in. Your bartenders are pretentious hipsters who need to learn basic customer service and how to run a bar efficiently. I’ve been a bartender for over 3 decades. They are jerks. Especially the women with the tattoos. Food was below ave. Paella was jard and al debts. Toast with gambas was charred black, not just in ends. I made a comment about it and got brushed off with a laugh. Valet is atrocious. I’ve never seen valet run like this. They don’t come to you and they don’t do any thing with a sense of urgency as you stand in 20 degree weather. It was odd. There were some great team members. Housekeeping was excellent. Meg, manager at restaurant was incredible. Friendly host stand. Good PM restaurant manager, who was friendly. The gym is incredible. Excellent facility. Too bad check in guy did not mention one word about hours or how to use it. Zero hotel overview. He was definitely not having a good day. I think he was annoyed with my dog who is more well behaved then him. Did not look at my note regarding that she is a certified service animal and the purpose for her requirements to travel with me. Room service was slow and hot food was below Luke warm. The art installation is the best I’ve seen At any 21c
Stayed 1 night in Jan 2026

10/10 Excellent

Dimitre

Travelled with group
Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026

6/10 Okay

Jolee

Travelled with group
Will not be staying here again. Room was below expectations for the price and not very clean. Restaurant and room service never answered the phone. Valet service was very kind and timely, gym and sauna were dirty, we stayed two nights and had to go to the lobby to get more toilet paper and clean towels after the calling the front desk for them they told us they didn’t have time.
Stayed 2 nights in Jan 2026

10/10 Excellent

Lawren

Stayed 1 night in Jan 2026

10/10 Excellent

Juanita

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026

10/10 Excellent

Lauren

Travelled with family
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Jan 2026