For our "end of cruise" 3 days in Rome, the Hotel Prati provided us close access to Vatican and the Rome tours we had booked. That is it's biggest benefit. There are endless Italian restaurants nearby.
As far as the room goes, we had a "Basic Double" room which was very tight offering a small open room with a bed and desk and a very small bathroom. Compared to our other hotel/motel rentals in our home country, Canada, Hotel Prati might be compared to a basic Motel 6 - just the basics, but very small in comparison.
On the good side, their continental breakfast from 7-10am was what you would expect for a continental breakfast, a variety of fruits, cereals and pastries, coffee and juice.
The front desk is manned 24hrs and they were most helpful in arranging taxis to the airport. It was nice that front desk persons spoke English, since our Italian is non-existent.