Compare Luxury Hotels in Southeast Missouri
More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)
We keep it easy with the option to pay now or later on select accommodation
Book up 'til the last second - millions of rooms to crash tonight^
Check hotel availability in Southeast Missouri
Featured Southeast Missouri Luxury Hotels

Super 8 by Wyndham Pevely

Motel 6 Poplar Bluff, MO

Days Inn and Suites by Wyndham Sikeston

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Pear Tree Inn Cape Girardeau Near the Medical Center

Comfort Inn Festus - St Louis South

Super 8 by Wyndham Poplar Bluff Missouri

Quality Inn Festus

Quality Inn
Luxury Hotels & Resorts in Southeast Missouri
What’s a holiday without a few upgrades here and there? Your busy life calls for an especially luxurious escape—even if you did just start thinking about it, and your annual leave starts tomorrow. But you don’t have to sacrifice A-list amenities and top-shelf touches just because you need to make a break for it; find luxury hotels in Southeast Missouri on lastminute.co.nz that’ll have you sinking into soft down pillows before Janice in accounting can catch up with you.
You may not be a celebrity, but there’s no reason you can’t be treated like one. Whether you require 2,000-thread-count sheets, perfectly veined Italian marble or down pillows made from the golden goose itself, luxury hotels near Southeast Missouri can deliver all that and more. Many of your accommodation options will offer oenophiles the chance to sip (or swill) prime wines, while fromage fanatics can chow down on fancy brie and camembert to their heart’s content. Need some sustenance to really soak up that wine? Now’s your chance to splurge on room service—it’s almost like having your own personal butler…almost.
Treat yo’self. Finding and booking our Southeast Missouri luxury hotels is a piece of cake. And speaking of cake—it should be delicious at your lavish lodging. So listen to your inner Paris Hilton and indulge yourself with the best of the best dining, service and comfort. With our discounts, you don’t have to be a regular at Tiffany & Co. to book the getaway of your dreams.
Southeast Missouri hotels essential information
Accommodation | 562 hotels |
---|---|
Lowest Price | NZ$111 |
Highest Price | NZ$184 |
Popular hotels | Super 8 by Wyndham Pevely, Motel 6 Poplar Bluff, MO, Days Inn and Suites by Wyndham Sikeston, Historical 'Kage House' Short Term Rental located in "Old Town Cape" , Pear Tree Inn Cape Girardeau Near the Medical Center, Comfort Inn Festus - St Louis South, Super 8 by Wyndham Poplar Bluff Missouri, Quality Inn Festus, Quality Inn |
Most recent Southeast Missouri hotel reviews

More Luxury Hotels
Other cities near Southeast Missouri
- Chesterfield Hotels
- Cape Girardeau Hotels
- Carbondale Hotels
- Sikeston Hotels
- Farmington Hotels
- Poplar Bluff Hotels
- Ste Genevieve Hotels
- Fenton Hotels
- Eminence Hotels
- East St. Louis Hotels
- Ozarks Hotels
- Kirkwood Hotels
- Arnold Hotels
- Richmond Heights Hotels
- West Plains Hotels
- Eureka Hotels
- Southern Illinois Hotels
- Dyersburg Hotels
- Brentwood Hotels
- Festus Hotels
Other top Southeast Missouri hotels
- Drury Plaza Hotel Cape Girardeau Conference Center
- Baymont Inn and Suites by Wyndham Farmington, MO
- Motel 6 Poplar Bluff, MO
- Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
- Pear Tree Inn Sikeston
- La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
- Fairfield Inn & Suites by Marriott Poplar Bluff
- Drury Inn & Suites Jackson MO
- La Quinta Inn & Suites by Wyndham Festus - St. Louis South
- Best Western Plus Sikeston
- Pear Tree Inn Cape Girardeau West
- Pear Tree Inn Cape Girardeau Near the Medical Center
- Drury Inn & Suites Cape Girardeau
- Hampton Inn Sikeston
- Drury Inn & Suites Sikeston, MO
- Candlewood Suites Cape Girardeau by IHG
- Comfort Inn Festus - St Louis South
- Days Inn and Suites by Wyndham Sikeston