Book Holiday Homes in Defiance

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Featured Holiday Homes in Defiance

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

Saint Charles MO
Stay at this holiday home in St. Charles. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Ameristar Casino St. Charles and Hollywood Casino ...
Opens in a new window🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!

St Charles MO
The price is NZ$452 per night from 11 May to 12 May
NZ$452
11 May - 12 May
includes taxes & fees
Stay at this family-friendly holiday home in St. Charles. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Ameristar Casino St. Charles ...
Opens in a new windowSt. Charles 1860's Gem - Sleeps 6!
Stunning 1890's Home - Sleeps 8!

Stunning 1890's Home - Sleeps 8!

Saint Charles MO
Stay at this holiday home in St. Charles. Enjoy laundry facilities and air conditioning. Popular attractions Ameristar Casino St. Charles and Hollywood Casino ...
Opens in a new windowStunning 1890's Home - Sleeps 8!
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The Lewis & Clark Hangout

The Lewis & Clark Hangout

Saint Charles MO
Stay at this holiday home in St. Charles. Enjoy laundry facilities, an in-room coffee maker and air conditioning. Popular attractions Ameristar Casino St. Charles ...
Opens in a new windowThe Lewis & Clark Hangout
 Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

St Charles MO
The price is NZ$437 per night from 8 June to 9 June
NZ$437
8 June - 9 June
includes taxes & fees
Stay at this holiday home in St. Charles. Enjoy laundry facilities, cable/satellite TV service and an in-room coffee maker. Popular attractions Ameristar Casino ...
Opens in a new window Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
 NEW 3-bedroom house in gorgeous O'Fallon

NEW 3-bedroom house in gorgeous O'Fallon

O'Fallon MO
Stay at this holiday home in O'Fallon. Enjoy a garden, laundry facilities and air conditioning. Popular attractions 9-11 Memorial and Alligator Creek Aquatic ...
Opens in a new window NEW 3-bedroom house in gorgeous O'Fallon
Retro Ranch With Private Indoor Pool & Sauna St Louis, MO

Retro Ranch With Private Indoor Pool & Sauna St Louis, MO

Saint Louis MO
Stay at this family-friendly holiday home in Ballwin. Enjoy free Wi-Fi, private pools and a sauna. Popular attractions Myseum and American Kennel Club Museum ...
Opens in a new windowRetro Ranch With Private Indoor Pool & Sauna St Louis, MO
Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!

Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!

Innsbrook MO
Stay at this holiday home in Wright City. Enjoy free Wi-Fi, a fitness centre and laundry facilities. Popular attractions Cardinal Lake and Wren Lake are located ...
Opens in a new windowGorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

Washington MO
The price is NZ$1,462 per night from 11 May to 12 May
NZ$1,462
11 May - 12 May
includes taxes & fees
Stay at this holiday home in Washington. Enjoy free Wi-Fi, private pools and laundry facilities. Popular attractions Miller-Post Nature Reserve and Big Driver ...
Opens in a new windowBeautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Defiance Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Defiance vacation homes are the perfect way for you to wing it.

Holiday houses in Defiance let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Defiance in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Defiance adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Defiance with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Defiance vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Defiance Holiday Homes essential information

Accommodation
261 Holiday Homes
Lowest Price
NZ$173
Highest Price
NZ$1,462
Popular accommodation
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟, St. Charles 1860's Gem - Sleeps 6!, Stunning 1890's Home - Sleeps 8! , The Lewis & Clark Hangout, Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!, NEW 3-bedroom house in gorgeous O'Fallon, Retro Ranch With Private Indoor Pool & Sauna St Louis, MO, Gorgeous Lakefront Getaway - Innsbrook Chalet with Outdoor Spa!, Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

Top trending hotels in Defiance

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
The price is NZ$174 per night from 17 May to 18 May
NZ$174
17 May - 18 May
includes taxes & fees
Stay at this business-friendly hotel in Fenton. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...
Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
The price is NZ$215 per night from 7 June to 8 June
NZ$215
7 June - 8 June
includes taxes & fees
Stay at this business-friendly hotel in Maryland Heights. Enjoy free parking, 7 restaurants and a casino. Our guests praise the helpful staff and the clean rooms ...
Opens in a new windowHollywood Casino & Hotel St. Louis
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
The price is NZ$341 per night from 25 May to 26 May
NZ$341
25 May - 26 May
includes taxes & fees
Stay at this luxury hotel in St. Charles. Enjoy a full-service spa, 6 restaurants and a casino. Our guests praise the clean rooms in their reviews. Popular attractions ...
Opens in a new windowAmeristar Casino Resort and Spa
Save an average of 15% on thousands of hotels when you're signed in
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
The price is NZ$173 per night from 25 May to 26 May
NZ$173
25 May - 26 May
includes taxes & fees
Stay at this business-friendly hotel in Wildwood. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the convenient parking ...
Opens in a new windowThe Wildwood Hotel
Don't see what you're looking for?
See all available properties in Defiance
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.