Disclaimer: not one to complain (check my reviews, I'm usually an easy going traveler). 
That stated, this is my third time staying at the Mark Spencer Hotel since covid and quite frankly, it's my favorite place in Portland (or rather, was). But this third time, it wasn't a charm. I stayed in a queen-bed size suite in floor 6 and there were (assuming) patrons above my room that were (to what sounds like) sliding their closet door intermittently throughout the duration of my stay (and you can hear it as though it was being drawn in my actual suite - crystal clear!). 
Conclusively, I heard it so many times that it severely disrupted my sleep (even with the fan on high and noise cancelling headphones on) and i struggled driving back to Seattle as I was so exhausted from lack of rest. 
There was also vocal noise from other patrons from corresponding rooms, but that was short lived and understandable (but the previous two times I stayed here, was situated in larger rooms and it was as quiet as a decommissioned library (yes, not a single bo-peep). 
Love the hotel, location and staff, but this made it unbearable and without being overly dramatic, when usually a stellar experience at this establishment, now left me with slight PTSD (as I'd be paranoid about running into this matter in future visits). 
This might have to be a no-go from me here on out (darn shame because everything else about it made it so fantastic). 
-B