Book Holiday Homes in Santee

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Featured Holiday Homes in Santee

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

Summerton SC
Stay at this beach holiday home in Summerton. Enjoy free Wi-Fi, a beach locale and a garden. Popular attractions Round Island and Wyboo Golf Club are located ...
Opens in a new windowSANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
The Bunkhouse at St Julien - Vintage Waterfront Lake House

The Bunkhouse at St Julien - Vintage Waterfront Lake House

Eutawville SC
Stay at this family-friendly holiday home in Eutawville. Enjoy a water park, a garden and laundry facilities. Popular attractions Pine Island and Ferguson Island ...
Opens in a new windowThe Bunkhouse at St Julien - Vintage Waterfront Lake House
Beautiful lake home to make your family vacation extra special!

Beautiful lake home to make your family vacation extra special!

Summerton SC
Stay at this holiday home in Summerton. Enjoy a garden, laundry facilities and an in-room coffee maker. Popular attractions Round Island and Goat Island are ...
Opens in a new windowBeautiful lake home to make your family vacation extra special!
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Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!

Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!

Summerton SC
Stay at this holiday home in Summerton. Enjoy free Wi-Fi, laundry facilities and cable/satellite TV service. Popular attractions Goat Island and Lake Marion ...
Opens in a new windowBeautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!
Beautiful Cottage between Lake Moultrie and Lake Marion

Beautiful Cottage between Lake Moultrie and Lake Marion

Cross SC
Stay at this holiday home in Cross. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Angel's Landing Marina and Lake Moultrie are located ...
Opens in a new windowBeautiful Cottage between Lake Moultrie and Lake Marion
Deep water Lake Marion house.  4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS

Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS

Summerton SC
Stay at this family-friendly holiday home in Summerton. Enjoy free Wi-Fi, a fitness centre and a garden. Our guests praise the helpful staff in their reviews. ...
Opens in a new windowDeep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy

Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy

Manning SC
Stay at this holiday home in Manning. Enjoy free Wi-Fi, laundry facilities and patios. Popular attractions Wyboo Golf Club and Round Island are located ...
Opens in a new windowLake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

4 out of 5
401 Bass Drive Santee SC
Stay at this holiday home in Santee. Enjoy free Wi-Fi, free parking and cable TV channels. Popular attractions Santee Cooper Country Club and Santee National ...
Opens in a new windowWyndham Vacation Resorts Lake Marion
New Listing SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable

New Listing SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable

Summerton SC
Stay at this beach holiday home in Summerton. Enjoy free Wi-Fi, a beach locale and a garden. Popular attractions Round Island and Wyboo Golf Club are located ...
Opens in a new windowNew Listing SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santee Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Santee vacation homes are the perfect way for you to wing it.

Holiday houses in Santee let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Santee in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Santee adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Santee with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Santee vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Santee Holiday Homes essential information

Accommodation
76 Holiday Homes
Lowest Price
NZ$154
Highest Price
NZ$232
Popular accommodation
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable, The Bunkhouse at St Julien - Vintage Waterfront Lake House , Beautiful lake home to make your family vacation extra special!, Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!, Beautiful Cottage between Lake Moultrie and Lake Marion , Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS, Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy, Wyndham Vacation Resorts Lake Marion, New Listing SANITIZED Lake Marion Lakefront! Ramp, Sleeps 13, Wi-Fi Cable

Top trending hotels in Santee

Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
The price is NZ$202 per night from 4 Jan to 5 Jan
NZ$202
4 Jan - 5 Jan 2026
includes taxes & fees
Stay at this hotel in Santee. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
Opens in a new windowTru By Hilton Santee
Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
The price is NZ$154 per night from 12 Jan to 13 Jan
NZ$154
12 Jan - 13 Jan 2026
includes taxes & fees
Stay at this business-friendly hotel in Santee. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their ...
Opens in a new windowBaymont by Wyndham Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy Santee SC
The price is NZ$232 per night from 13 Jan to 14 Jan
NZ$232
13 Jan - 14 Jan 2026
includes taxes & fees
Stay at this hotel in Santee. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
Opens in a new windowFairfield Inn & Suites by Marriott Santee
Save an average of 15% on thousands of hotels when you're signed in
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
The price is NZ$227 per night from 14 Jan to 15 Jan
NZ$227
14 Jan - 15 Jan 2026
includes taxes & fees
Stay at this hotel in Santee. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
Opens in a new windowHampton Inn Santee-I-95
Don't see what you're looking for?
See all available properties in Santee
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.